Sometimes it is not possible to drill a deep straight hole. The material may prevent it.
A few years ago I was rebuilding the piston valves on a Gauge 1 locomotive. The manufacturer had done a very nice job of cylindrical grinding the piston part but the sleeve was a push fit had a terrible surface finish. I decided to put cast iron liners in and lap them to fit the existing piston. These liners needed to be about 5/16 OD with a 4mm hole for the piston. No problem as I had the correct size drill and reamer.
Cast iron on hand was 1 inch diameter Class 40 gray iron. Well going from 1 inch to 5/16 inch sure makes a lot of cast iron chips and I wanted to make 4 parts, two for repair and 2 spares for another locomotive. Took a suitable length of 1 inch and quartered it so I had 4 pie shaped lengths large enough to get the 5/16 OD out of with plenty to spare. Turned them up round with the 4 jaw chuck then put them in a collet a cleaned up to length.
OK, first part. center drilled, drilled and reamed and removed from collet to do the lapping operation after I did the next three. Looked at the far end and the hole came out about 0.020 off center. Well I am still OK as I really only need 2 right now. Maybe I screwed up something. Next part I checked all the lathe alignment and the resultant part was still 0.020 off center at the far end. Third part. Drilled an undersize hole about 1/4 inch deep and opened it up to the drill size with a small boring bar. Same result as before after drilling and reaming. The hole was a nice curved hole, but quite consistent about how much off center the exit point was. So now I am down to one blank and I needed 2 parts.
About this time the light comes on. I had gotten the same result 3 times in a row. The cast iron was varying in density/hardness from the center to the outside and the drill was pulling toward the softer side. OK, I have a big vacuum cleaner for dust pick up so starting with a 1 inch diameter I turned it down to my required OD. Then into the collet as same center drill/drill/ream procedure as before. I could not measure any runout on the exit hole.
What does that have to do with your crankcase you ask? Well maybe nothing, but thinking back to when Tony (Cobra428) was building his Whittle V8 he had to make several crankcases as I recall to get his camshaft hole to run straight. I had done the same crankcase a few months before and I had no problem. While I did not think of it at the time, I think he was using extruded barstock, and I had used cast 6061 tooling plate that had been heat treated and ground so it would not warp during machining. I don't know, but suspect that the camshaft hole was near one edge of the stock and that residual stresses in the material was causing the hole to wander on his.
Like I said, I don't know if this has any bearing on your problem, but it might stimulate some other thoughts.
Gail in NM